Diclofenac metabolic pathway
Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J. Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol. 1999 Sep 01;58(5):787–96. doi: 10.1016/s0006-2952(99)00167-7. PMID: 10449188.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.14.13.- | |||
| 1.14.14.1 | unspecific monooxygenase | substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) | |
| 1.14.14.51 | (S)-limonene 6-monooxygenase | (S)-limonene,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating) | |
| 1.14.14.52 | (S)-limonene 7-monooxygenase | (S)-limonene,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (7-hydroxylating) | |
| 1.14.14.53 | (R)-limonene 6-monooxygenase | (R)-limonene,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (6-hydroxylating) | |
| 1.14.14.75 | fenbendazole monooxygenase (4'-hydroxylating) | fenbendazole,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (4'-hydroxylating) |
Proteins
| Protein ID | name | full name |
|---|