PDGFR-alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine

Jun HJ, Appleman VA, Wu H, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A. A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nature Communications. 2018 Aug 06;9(1):3116. doi: 10.1038/s41467-018-05036-4.

Metabolites

Vinblastine

Formula: C46H58N4O9 (810.4203578)

CAS ID: 865-21-4



Enzyme

EC Number name full name note


Proteins

Protein ID name full name