Elongation of (very) long chain fatty acids

Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity. Nature. 2019 Feb;566(7744):403–6. PMID: 30728499; PMCID: PMC6390935.

Metabolites

(9Z)-Hexadecenoic acid

Formula: C16H30O2 (254.224568)

CAS ID: 373-49-9

(9Z)-Octadecenoic acid

Formula: C18H34O2 (282.2558664)

CAS ID: 112-80-1

Adrenic acid

Formula: C22H36O2 (332.2715156)

CAS ID: 28874-58-0

Arachidonate

Formula: C20H32O2 (304.24021719999996)

CAS ID: 506-32-1

Cerotic acid

Formula: C26H52O2 (396.3967092)

CAS ID: 506-46-7

cis-Vaccenic acid

Formula: C18H34O2 (282.2558664)

CAS ID: 506-17-2

Dihomo-gamma-linolenate

Formula: C20H34O2 (306.2558664)

CAS ID: 1783-84-2

Docosanoic acid

Formula: C22H44O2 (340.3341124)

CAS ID: 112-85-6

Erucic acid

Formula: C22H42O2 (338.3184632)

CAS ID: 112-86-7

Hexadecanoic acid

Formula: C16H32O2 (256.2402172)

CAS ID: 57-10-3

Icosadienoic acid

Formula: C20H36O2 (308.2715156)

CAS ID: 5598-38-9

Icosanoic acid

Formula: C20H40O2 (312.302814)

CAS ID: 506-30-9

Icosatrienoic acid

Formula: C20H34O2 (306.2558664)

CAS ID: 17046-59-2

Icosenoic acid

Formula: C20H38O2 (310.28716479999997)

CAS ID: 5561-99-9

Linoleate

Formula: C18H32O2 (280.2402172)

CAS ID: 60-33-3

Mead acid

Formula: C20H34O2 (306.2558664)

CAS ID: 20590-32-3

Montanic acid

Formula: C28H56O2 (424.4280076)

CAS ID: 506-48-9

Octadecanoic acid

Formula: C18H36O2 (284.2715156)

CAS ID: 57-11-4

Sapienic acid

Formula: C16H30O2 (254.224568)

CAS ID: 17004-51-2

Stearidonic acid

Formula: C18H28O2 (276.2089188)

CAS ID: 20290-75-9

Tetracosanoic acid

Formula: C24H48O2 (368.36541079999995)

CAS ID: 557-59-5

Docosapentaenoic acid (22n-6)

Formula: C22H34O2 (330.2558664)

CAS ID: 25448-00-4

Tetracosahexaenoic acid

Formula: C24H36O2 (356.2715156)

CAS ID: 81247-23-6

Melissic acid A

Formula: C30H60O2 (452.45930599999997)

CAS ID: 506-50-3

6Z,9Z-octadecadienoic acid

Formula: C18H32O2 (280.2402172)

CAS ID: 28290-77-9

34:6(16Z,19Z,22Z,25Z,28Z,31Z)

Formula: C34H56O2 (496.4280076)

CAS ID: 105528-06-1



Enzyme

EC Number name full name note
1.14.19.-
1.14.19.1 stearoyl-CoA 9-desaturase stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)


Proteins

Protein ID name full name