Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Yang W. An overview of Y-Family DNA polymerases and a case study of human DNA polymerase ?. Biochemistry. 2014 May 06;53(17):2793–803. PMID: 24716551; PMCID: PMC4018060.; Masutani C, Kusumoto R, Iwai S, Hanaoka F. Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J. 2000 Jun 15;19(12):3100–9. PMID: 10856253; PMCID: PMC203367.; Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.3.1.- | |||
| 2.7.7.7 | DNA-directed DNA polymerase | deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 | ||
| 3.6.4.6 | vesicle-fusing ATPase | ATP phosphohydrolase (vesicle-fusing) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| O42917 | eso1 | N-acetyltransferase eso1 |
| O74944 | mug40 | DNA polymerase kappa |
| O94269 | ubp3 | Probable ubiquitin carboxyl-terminal hydrolase 3 |
| O94623 | rev1 | DNA repair protein rev1 |
| P30316 | pol3 | DNA polymerase delta catalytic subunit |
| P87154 | pol2 | DNA polymerase epsilon catalytic subunit A |
| P87324 | cdc1 | DNA polymerase subunit delta-2 |
| Q9P3A7 | cdc48 | Cell division cycle protein 48 |
| Q9P6L6 | rev3 | DNA polymerase zeta catalytic subunit |