Regulation of TP53 Activity

Mantovani F, Zannini A, Rustighi A, Del Sal G. Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships. Biochimica et Biophysica Acta (BBA) - General Subjects. 2015 Oct;1850(10):2048–60. doi: 10.1016/j.bbagen.2015.01.013.; Santiago A, Li D, Zhao LY, Godsey A, Liao D. p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1. Mol Biol Cell. 2013 Sep;24(17):2739–52. PMID: 23825024; PMCID: PMC3756925.; Meek DW, Anderson CW. Posttranslational Modification of p53: Cooperative Integrators of Function. Cold Spring Harbor Perspectives in Biology. 2009 Oct 28;1(6):a000950. doi: 10.1101/cshperspect.a000950.; Kruse JP, Gu W. Modes of p53 regulation. Cell. 2009 May 15;137(4):609–22. PMID: 19450511; PMCID: PMC3737742.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase


Proteins

Protein ID name full name
O13853 its3 Phosphatidylinositol 4-phosphate 5-kinase its3
O74448 pin1 Peptidyl-prolyl cis-trans isomerase pin1
Q12701 ksg1 Serine/threonine-protein kinase ksg1
Q9Y7K2 tor2 Serine/threonine-protein kinase tor2