DNA strand elongation

Bambara RA, Murante RS, Henricksen LA. Enzymes and Reactions at the Eukaryotic DNA Replication Fork. Journal of Biological Chemistry. 1997 Feb;272(8):4647–50. doi: 10.1074/jbc.272.8.4647.; Ayyagari R, Impellizzeri KJ, Yoder BL, Gary SL, Burgers PMJ. A Mutational Analysis of the Yeast Proliferating Cell Nuclear Antigen Indicates Distinct Roles in DNA Replication and DNA Repair. Molecular and Cellular Biology. 1995 Aug 01;15(8):4420–9. doi: 10.1128/mcb.15.8.4420.; Brush GS, Kelly TJ, Stillman B. Identification of eukaryotic DNA replication proteins using simian virus 40 in vitro replication system. Methods Enzymol. 1995;262():522–48. doi: 10.1016/0076-6879(95)62043-5. PMID: 8594377.; Marahrens Y, Stillman B. A yeast chromosomal origin of DNA replication defined by multiple functional elements. Science. 1992 Feb 14;255(5046):817–23. doi: 10.1126/science.1536007. PMID: 1536007.; Hurwitz J, Dean FB, Kwong AD, Lee SH. The in vitro replication of DNA containing the SV40 origin. Journal of Biological Chemistry. 1990 Oct;265(30):18043–6. doi: 10.1016/s0021-9258(17)44708-9.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.-.-
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
5.6.2.3 DNA 5'-3' helicase DNA 5'-3' helicase (ATP-hydrolysing)
6.5.1.1 DNA ligase (ATP) poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP)


Proteins

Protein ID name full name
P12000 cdc17 DNA ligase 1
P30316 pol3 DNA polymerase delta catalytic subunit
P39750 rad2 Flap endonuclease 1
P87324 cdc1 DNA polymerase subunit delta-2
Q9URU2 dna2 DNA replication ATP-dependent helicase/nuclease dna2