G alpha (q) signalling events

Mizuno N, Itoh H. Functions and regulatory mechanisms of Gq-signaling pathways. Neurosignals. 2009;17(1):42–54. doi: 10.1159/000186689. PMID: 19212139.; Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6457–62. PMID: 18434541; PMCID: PMC2359823.; COUGHLIN SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. Journal of Thrombosis and Haemostasis. 2005 Aug;3(8):1800–14. doi: 10.1111/j.1538-7836.2005.01377.x.; Ma YC, Huang XY. Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12197–201. PMID: 9770463; PMCID: PMC22808.; Offermanns S, Toombs CF, Hu YH, Simon MI. Defective platelet activation in G alpha(q)-deficient mice. Nature. 1997 Sep 11;389(6647):183–6. doi: 10.1038/38284. PMID: 9296496.

Metabolites

2-Arachidonoylglycerol

Formula: C23H38O4 (378.2769948)

CAS ID: 53847-30-6

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.1.23 acylglycerol lipase glycerol-ester acylhydrolase
3.1.1.3 triacylglycerol lipase triacylglycerol acylhydrolase


Proteins

Protein ID name full name
P24583 PKC1 Protein kinase C-like 1
P28321 YJU3 Monoglyceride lipase
P38070 YPK3 Serine/threonine-protein kinase YPK3
P38139 LDH1 Lipid droplet hydrolase 1
Q00772 SLT2 Mitogen-activated protein kinase SLT2/MPK1