Signaling by GPCR
Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999 Apr 01;18(7):1723–9. PMID: 10202136; PMCID: PMC1171258.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 2.7.11.13 | protein kinase C | ATP:protein phosphotransferase (diacylglycerol-dependent) | |
| 2.7.11.24 | mitogen-activated protein kinase | ATP:protein phosphotransferase (MAPKK-activated) | |
| 3.1.1.23 | acylglycerol lipase | glycerol-ester acylhydrolase | |
| 3.1.1.3 | triacylglycerol lipase | triacylglycerol acylhydrolase | |
| 3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase | 3',5'-cyclic-AMP 5'-nucleotidohydrolase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P06776 | PDE2 | 3',5'-cyclic-nucleotide phosphodiesterase 2 |
| P24583 | PKC1 | Protein kinase C-like 1 |
| P28321 | YJU3 | Monoglyceride lipase |
| P38070 | YPK3 | Serine/threonine-protein kinase YPK3 |
| P38139 | LDH1 | Lipid droplet hydrolase 1 |
| Q00772 | SLT2 | Mitogen-activated protein kinase SLT2/MPK1 |
| Q12236 | PKH2 | Serine/threonine-protein kinase PKH2 |