VEGFR2 mediated cell proliferation

Koch S, Claesson-Welsh L. Signal Transduction by Vascular Endothelial Growth Factor Receptors. Cold Spring Harbor Perspectives in Medicine. 2012 Mar 06;2(7):a006502. doi: 10.1101/cshperspect.a006502.; Berger P, Ballmer-Hofer K. The reception and the party after: how vascular endothelial growth factor receptor 2 explores cytoplasmic space. Swiss Med Wkly. 2011;141():w13318. doi: 10.4414/smw.2011.13318. PMID: 22180219.; Shibuya M. Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. Genes & Cancer. 2011 Oct 03;2(12):1097–105. doi: 10.1177/1947601911423031.; Clark JA, Black AR, Leontieva OV, Frey MR, Pysz MA, Kunneva L, Woloszynska-Read A, Roy D, Black JD. Involvement of the ERK Signaling Cascade in Protein Kinase C-mediated Cell Cycle Arrest in Intestinal Epithelial Cells. Journal of Biological Chemistry. 2004 Mar;279(10):9233–47. doi: 10.1074/jbc.m312268200.; Wu W, Shu X, Hovsepyan H, Mosteller RD, Broek D. VEGF receptor expression and signaling in human bladder tumors. Oncogene. 2003 May 29;22(22):3361–70. doi: 10.1038/sj.onc.1206285. PMID: 12776187.; Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marmé D, Rapp UR. Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature. 1993 Jul 15;364(6434):249–52. doi: 10.1038/364249a0. PMID: 8321321.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)


Proteins

Protein ID name full name
P24583 PKC1 Protein kinase C-like 1
Q12236 PKH2 Serine/threonine-protein kinase PKH2