PI5P Regulates TP53 Acetylation

Bultsma Y, Keune WJ, Divecha N. PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha. Biochem J. 2010 Sep 01;430(2):223–35. doi: 10.1042/bj20100341. PMID: 20583997.; Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16834–9. PMID: 17940011; PMCID: PMC2040409.; Jones DR, Bultsma Y, Keune WJ, Halstead JR, Elouarrat D, Mohammed S, Heck AJ, D'Santos CS, Divecha N. Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Mol Cell. 2006 Sep 01;23(5):685–95. doi: 10.1016/j.molcel.2006.07.014. PMID: 16949365.; Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11;114(1):99–111. doi: 10.1016/s0092-8674(03)00480-x. PMID: 12859901.; Ciruela A, Hinchliffe KA, Divecha N, Irvine RF. Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7. Biochem J. 2000 Mar 15;346 Pt 3():587–91. PMID: 10698683; PMCID: PMC1220889.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase


Proteins

Protein ID name full name
P22696 ESS1 Peptidyl-prolyl cis-trans isomerase ESS1
P38994 MSS4 Phosphatidylinositol 4-phosphate 5-kinase MSS4