EPH-ephrin mediated repulsion of cells

Lin K, Sloniowski S, Ethell DW, Ethell IM. Ephrin-B2-induced Cleavage of EphB2 Receptor Is Mediated by Matrix Metalloproteinases to Trigger Cell Repulsion. Journal of Biological Chemistry. 2008 Oct;283(43):28969–79. doi: 10.1074/jbc.m804401200.; Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230–8. doi: 10.1016/j.tcb.2007.03.004. PMID: 17420126.; Janes PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, Nievergall E, Blobel CP, Himanen JP, Lackmann M, Nikolov DB. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell. 2005 Oct 21;123(2):291–304. doi: 10.1016/j.cell.2005.08.014. PMID: 16239146.; Marston DJ, Dickinson S, Nobes CD. Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat Cell Biol. 2003 Oct;5(10):879–88. doi: 10.1038/ncb1044. PMID: 12973357.; Hattori M, Osterfield M, Flanagan JG. Regulated cleavage of a contact-mediated axon repellent. Science. 2000 Aug 25;289(5483):1360–5. doi: 10.1126/science.289.5483.1360. PMID: 10958785.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name