NIK-->noncanonical NF-kB signaling

Plato A, Willment JA, Brown GD. C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways. International Reviews of Immunology. 2013 Apr 09;32(2):134–56. doi: 10.3109/08830185.2013.777065.; Razani B, Reichardt AD, Cheng G. Non-canonical NF-?B signaling activation and regulation: principles and perspectives. Immunol Rev. 2011 Nov;244(1):44–54. doi: 10.1111/j.1600-065x.2011.01059.x. PMID: 22017430.; Sun SC. Non-canonical NF-?B signaling pathway. Cell Res. 2011 Jan;21(1):71–85. PMID: 21173796; PMCID: PMC3193406.; Geijtenbeek TB, Gringhuis SI. Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol. 2009 Jul;9(7):465–79. PMID: 19521399; PMCID: PMC7097056.; Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009;27():693–733. doi: 10.1146/annurev.immunol.021908.132641. PMID: 19302050.; Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol. 2009 Feb;10(2):203–13. doi: 10.1038/ni.1692. PMID: 19122653.; Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, Sammut B, O'Neal J, Zou W, Weilbaecher KN, Faccio R, Novack DV. RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3897–902. PMID: 18322009; PMCID: PMC2268780.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
6.2.1.64 E1 NEDD8-activating enzyme [NEDD8 protein]:[E1 NEDD8-activating enzyme] ligase (AMP-forming)


Proteins

Protein ID name full name