Deactivation of the beta-catenin transactivating complex

Voronina VA, Takemaru K, Treuting P, Love D, Grubb BR, Hajjar AM, Adams A, Li FQ, Moon RT. Inactivation of Chibby affects function of motile airway cilia. J Cell Biol. 2009 Apr 20;185(2):225–33. PMID: 19364920; PMCID: PMC2700371.; Song L, Gelmann EP. Silencing Mediator for Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Attenuate Transcriptional Activation by the ß-Catenin-TCF4 Complex. Journal of Biological Chemistry. 2008 Sep;283(38):25988–99. doi: 10.1074/jbc.m800325200.; Li FQ, Mofunanya A, Harris K, Takemaru K. Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity. J Cell Biol. 2008 Jun 30;181(7):1141–54. PMID: 18573912; PMCID: PMC2442201.; Weiske J, Albring KF, Huber O. The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20344–9. PMID: 18077326; PMCID: PMC2154433.; Sierra J, Yoshida T, Joazeiro CA, Jones KA. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 2006 Mar 01;20(5):586–600. PMID: 16510874; PMCID: PMC1410807.; Hamada F, Bienz M. The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell. 2004 Nov;7(5):677–85. doi: 10.1016/j.devcel.2004.08.022. PMID: 15525529.; Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT. Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Nature. 2003 Apr 24;422(6934):905–9. doi: 10.1038/nature01570. PMID: 12712206.; Graham TA, Clements WK, Kimelman D, Xu W. The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. Mol Cell. 2002 Sep;10(3):563–71. doi: 10.1016/s1097-2765(02)00637-8. PMID: 12408824.; Daniels DL, Weis WI. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell. 2002 Sep;10(3):573–84. doi: 10.1016/s1097-2765(02)00631-7. PMID: 12408825.; Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J. Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J. 2000 Nov 15;19(22):6121–30. PMID: 11080158; PMCID: PMC305835.; Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000 Jul 15;14(14):1741–9. PMID: 10898789; PMCID: PMC316784.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.1.1.-
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
3.5.1.98 histone deacetylase histone amidohydrolase


Proteins

Protein ID name full name