MAP2K and MAPK activation

Roskoski R. ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol Res. 2012 Aug;66(2):105–43. doi: 10.1016/j.phrs.2012.04.005. PMID: 22569528.; Roskoski R. MEK1/2 dual-specificity protein kinases: Structure and regulation. Biochemical and Biophysical Research Communications. 2012 Jan;417(1):5–10. doi: 10.1016/j.bbrc.2011.11.145.; Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W. Raf Family Kinases: Old Dogs Have Learned New Tricks. Genes & Cancer. 2011 Mar 01;2(3):232–60. doi: 10.1177/1947601911407323.; Roskoski R. RAF protein-serine/threonine kinases: Structure and regulation. Biochemical and Biophysical Research Communications. 2010 Aug;399(3):313–7. doi: 10.1016/j.bbrc.2010.07.092.; Brown MD, Sacks DB. Protein scaffolds in MAP kinase signalling. Cellular Signalling. 2009 Apr;21(4):462–9. doi: 10.1016/j.cellsig.2008.11.013.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)


Proteins

Protein ID name full name