Activation of PKB

Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cellular Mol Med. 2005 Jan;9(1):59–71. doi: 10.1111/j.1582-4934.2005.tb00337.x.; Peterson RT, Schreiber SL. Kinase phosphorylation: Keeping it all in the family. Curr Biol. 1999 Jul 15;9(14):R521–4. doi: 10.1016/s0960-9822(99)80326-1. PMID: 10421571.; Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA. Role of Translocation in the Activation and Function of Protein Kinase B. Journal of Biological Chemistry. 1997 Dec;272(50):31515–24. doi: 10.1074/jbc.272.50.31515.; Frech M, Andjelkovic M, Ingley E, Reddy KK, Falck JR, Hemmings BA. High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity. Journal of Biological Chemistry. 1997 Mar;272(13):8474–81. doi: 10.1074/jbc.272.13.8474.; Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. Mechanism of activation of protein kinase B by insulin and IGF-1. The EMBO Journal. 1996 Dec;15(23):6541–51. doi: 10.1002/j.1460-2075.1996.tb01045.x.; James SR, Downes CP, Gigg R, Grove SJ, Holmes AB, Alessi DR. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochem J. 1996 May 01;315 ( Pt 3)():709–13. PMID: 8645147; PMCID: PMC1217264.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name