Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

Marti TM, Kunz C, Fleck O. DNA mismatch repair and mutation avoidance pathways. Journal Cellular Physiology. 2002 Feb 19;191(1):28–41. doi: 10.1002/jcp.10077.; Genschel J, Littman SJ, Drummond JT, Modrich P. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J Biol Chem. 1998 Jul 31;273(31):19895–901. doi: 10.1074/jbc.273.31.19895. PMID: 9677427.; Marra G, Iaccarino I, Lettieri T, Roscilli G, Delmastro P, Jiricny J. Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proc. Natl. Acad. Sci. U.S.A. 1998 Jul 21;95(15):8568–73. doi: 10.1073/pnas.95.15.8568.; Drummond JT, Genschel J, Wolf E, Modrich P. DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSa/hMutSß ratio and reduces the efficiency of base–base mismatch repair. Proc. Natl. Acad. Sci. U.S.A. 1997 Sep 16;94(19):10144–9. doi: 10.1073/pnas.94.19.10144.; Palombo F, Iaccarino I, Nakajima E, Ikejima M, Shimada T, Jiricny J. hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr Biol. 1996 Sep 01;6(9):1181–4. doi: 10.1016/s0960-9822(02)70685-4. PMID: 8805365.

Metabolites



Enzyme

EC Number name full name note
3.1.11.-
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
6.5.1.1 DNA ligase (ATP) poly(deoxyribonucleotide)-3'-hydroxyl:5'-phospho-poly(deoxyribonucleotide) ligase (ATP)


Proteins

Protein ID name full name