Interleukin-6 family signaling

Nitz R, Lokau J, Aparicio-Siegmund S, Scheller J, Garbers C. Modular organization of Interleukin-6 and Interleukin-11 a-receptors. Biochimie. 2015 Dec;119():175–82. doi: 10.1016/j.biochi.2015.11.005. PMID: 26551279.; Mousa A, Bakhiet M. Role of cytokine signaling during nervous system development. Int J Mol Sci. 2013 Jul 04;14(7):13931–57. PMID: 23880850; PMCID: PMC3742226.; Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B. Signaling by IL-31 and functional consequences. European Journal of Cell Biology. 2012 Jun;91(6-7):552–66. doi: 10.1016/j.ejcb.2011.07.006.; Garbers C, Hermanns HM, Schaper F, Müller-Newen G, Grötzinger J, Rose-John S, Scheller J. Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev. 2012 Jun;23(3):85–97. doi: 10.1016/j.cytogfr.2012.04.001. PMID: 22595692.; Kopf M, Bachmann MF, Marsland BJ. Averting inflammation by targeting the cytokine environment. Nat Rev Drug Discov. 2010 Sep;9(9):703–18. doi: 10.1038/nrd2805. PMID: 20811382.; Kishimoto T. IL-6: from its discovery to clinical applications. International Immunology. 2010 Apr 21;22(5):347–52. doi: 10.1093/intimm/dxq030.; Briso EM, Dienz O, Rincon M. Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J Immunol. 2008 Jun 01;180(11):7102–6. PMID: 18490707; PMCID: PMC2692633.; Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003 Aug 15;374(Pt 1):1–20. PMID: 12773095; PMCID: PMC1223585.; Heinrich PC, Behrmann I, Müller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 1998 Sep 01;334 ( Pt 2)():297–314. PMID: 9716487; PMCID: PMC1219691.; Nakashima K, Taga T. gp130 and the IL-6 family of cytokines: signaling mechanisms and thrombopoietic activities. Semin Hematol. 1998 Jul;35(3):210–21. PMID: 9685167.; Taga T, Kishimoto T. gp130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES. Annu. Rev. Immunol. 1997 Apr;15(1):797–819. doi: 10.1146/annurev.immunol.15.1.797.; Taga T. Gp130, a shared signal transducing receptor component for hematopoietic and neuropoietic cytokines. J Neurochem. 1996 Jul;67(1):1–10. doi: 10.1046/j.1471-4159.1996.67010001.x. PMID: 8666978.; Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. 1995 Aug 15;86(4):1243–54. doi: 10.1182/blood.v86.4.1243.bloodjournal8641243.; Rozwarski DA, Gronenborn AM, Clore GM, Bazan JF, Bohm A, Wlodawer A, Hatada M, Karplus PA. Structural comparisons among the short-chain helical cytokines. Structure. 1994 Mar 15;2(3):159–73. doi: 10.1016/s0969-2126(00)00018-6. PMID: 8069631.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name