Interleukin-2 signaling

Malek TR. The biology of interleukin-2. Annu Rev Immunol. 2008;26():453–79. doi: 10.1146/annurev.immunol.26.021607.090357. PMID: 18062768.; Burchill MA, Yang J, Vang KB, Farrar MA. Interleukin-2 receptor signaling in regulatory T cell development and homeostasis. Immunology Letters. 2007 Nov;114(1):1–8. doi: 10.1016/j.imlet.2007.08.005.; Lindemann MJ, Benczik M, Gaffen SL. Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit. J Biol Chem. 2003 Mar 21;278(12):10239–49. doi: 10.1074/jbc.m209471200. PMID: 12525482.; Takeshita T, Ohtani K, Asao H, Kumaki S, Nakamura M, Sugamura K. An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex. 1992 Apr 01;148(7):2154–8. doi: 10.4049/jimmunol.148.7.2154.; Wang HM, Smith KA. The interleukin 2 receptor. Functional consequences of its bimolecular structure. J Exp Med. 1987 Oct 01;166(4):1055–69. PMID: 3116143; PMCID: PMC2188729.; Teshigawara K, Wang HM, Kato K, Smith KA. Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 1987 Jan 01;165(1):223–38. PMID: 3098894; PMCID: PMC2188268.; Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ. Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science. 1986 Nov 14;234(4778):859–63. doi: 10.1126/science.3095922. PMID: 3095922.; Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature. 1982 Nov 18;300(5889):267–9. doi: 10.1038/300267a0. PMID: 6815536.; Robb RJ, Munck A, Smith KA. T cell growth factor receptors. Quantitation, specificity, and biological relevance. J Exp Med. 1981 Nov 01;154(5):1455–74. PMID: 6975347; PMCID: PMC2186509.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)


Proteins

Protein ID name full name