CD28 dependent Vav1 pathway

Tybulewicz VL. Vav-family proteins in T-cell signalling. Curr Opin Immunol. 2005 Jun;17(3):267–74. doi: 10.1016/j.coi.2005.04.003. PMID: 15886116.; Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE. CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells. J Immunol. 2003 Sep 01;171(5):2225–32. doi: 10.4049/jimmunol.171.5.2225. PMID: 12928366.; Tybulewicz VL, Ardouin L, Prisco A, Reynolds LF. Vav1: a key signal transducer downstream of the TCR. Immunol Rev. 2003 Apr;192():42–52. doi: 10.1034/j.1600-065x.2003.00032.x. PMID: 12670394.; Hehner SP, Hofmann TG, Dienz O, Dröge W, Schmitz ML. Tyrosine-phosphorylated Vav1 as a Point of Integration for T-cell Receptor- and CD28-mediated Activation of JNK, p38, and Interleukin-2 Transcription. Journal of Biological Chemistry. 2000 Jun;275(24):18160–71. doi: 10.1074/jbc.275.24.18160.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name