Regulation of RUNX3 expression and activity
Paudel D, Zhou W, Ouyang Y, Dong S, Huang Q, Giri R, Wang J, Tong X. MicroRNA-130b functions as a tumor suppressor by regulating RUNX3 in epithelial ovarian cancer. Gene. 2016 Jul 15;586(1):48–55. doi: 10.1016/j.gene.2016.04.001. PMID: 27048832.; Whittle MC, Izeradjene K, Rani PG, Feng L, Carlson MA, DelGiorno KE, Wood LD, Goggins M, Hruban RH, Chang AE, Calses P, Thorsen SM, Hingorani SR. RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma. Cell. 2015 Jun 04;161(6):1345–60. PMID: 26004068; PMCID: PMC4458240.; Kim DY, Kwon E, Hartley PD, Crosby DC, Mann S, Krogan NJ, Gross JD. CBFß stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell. 2013 Feb 21;49(4):632–44. PMID: 23333304; PMCID: PMC3582769.; Lai KW, Koh KX, Loh M, Tada K, Subramaniam MM, Lim XY, Vaithilingam A, Salto-Tellez M, Iacopetta B, Ito Y, Soong R; Singapore Gastric Cancer Consortium. MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. Eur J Cancer. 2010 May;46(8):1456–63. doi: 10.1016/j.ejca.2010.01.036. PMID: 20176475.; Goh Y, Cinghu S, Hong ETH, Lee Y, Kim J, Jang J, Li Y, Chi X, Lee K, Wee H, Ito Y, Oh B, Bae S. Src Kinase Phosphorylates RUNX3 at Tyrosine Residues and Localizes the Protein in the Cytoplasm. Journal of Biological Chemistry. 2010 Mar;285(13):10122–9. doi: 10.1074/jbc.m109.071381.; Chi XZ, Kim J, Lee YH, Lee JW, Lee KS, Wee H, Kim WJ, Park WY, Oh BC, Stein GS, Ito Y, van Wijnen AJ, Bae SC. Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination. Cancer Res. 2009 Oct 15;69(20):8111–9. PMID: 19808967; PMCID: PMC3059505.; Lee SH, Kim J, Kim WH, Lee YM. Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. Oncogene. 2009 Jan 15;28(2):184–94. doi: 10.1038/onc.2008.377. PMID: 18850007.; Kim HR, Oh BC, Choi JK, Bae SC. Pim-1 kinase phosphorylates and stabilizes RUNX3 and alters its subcellular localization. J Cell Biochem. 2008 Nov 01;105(4):1048–58. doi: 10.1002/jcb.21906. PMID: 18767071.; Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J Biol Chem. 2004 Jul 09;279(28):29409–17. doi: 10.1074/jbc.m313120200. PMID: 15138260.; Levanon D, Groner Y. Structure and regulated expression of mammalian RUNX genes. Oncogene. 2004 May 24;23(24):4211–9. doi: 10.1038/sj.onc.1207670. PMID: 15156175.