Regulation of TP53 Expression and Degradation
Wade M, Li YC, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 2013 Feb;13(2):83–96. PMID: 23303139; PMCID: PMC4161369.; Cheng Q, Cross B, Li B, Chen L, Li Z, Chen J. Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage. Molecular and Cellular Biology. 2011 Dec 01;31(24):4951–63. doi: 10.1128/mcb.05553-11.; Saldaña-Meyer R, Recillas-Targa F. Transcriptional and epigenetic regulation of the p53 tumor suppressor gene. Epigenetics. 2011 Sep 01;6(9):1068–77. doi: 10.4161/epi.6.9.16683. PMID: 21814038.; Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B. MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 2009 Apr 01;23(7):862–76. PMID: 19293287; PMCID: PMC2666337.; Mahmoudi S, Henriksson S, Corcoran M, Méndez-Vidal C, Wiman KG, Farnebo M. Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. Mol Cell. 2009 Feb 27;33(4):462–71. doi: 10.1016/j.molcel.2009.01.028. PMID: 19250907.; Toledo F, Wahl GM. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. The International Journal of Biochemistry & Cell Biology. 2007 Jul;39(7-8):1476–82. doi: 10.1016/j.biocel.2007.03.022.; Yang W, Rozan LM, McDonald ER, Navaraj A, Liu JJ, Matthew EM, Wang W, Dicker DT, El-Deiry WS. CARPs Are Ubiquitin Ligases That Promote MDM2-independent p53 and Phospho-p53ser20 Degradation. Journal of Biological Chemistry. 2007 Feb;282(5):3273–81. doi: 10.1074/jbc.m610793200.; Takagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005 Oct 07;123(1):49–63. doi: 10.1016/j.cell.2005.07.034. PMID: 16213212.; Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR. MAPKAP Kinase 3pK Phosphorylates and Regulates Chromatin Association of the Polycomb Group Protein Bmi1. Journal of Biological Chemistry. 2005 Feb;280(7):5178–87. doi: 10.1074/jbc.m407155200.; Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature. 2004 May 06;429(6987):86–92. doi: 10.1038/nature02514. PMID: 15103385.; Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell. 2003 Mar 21;112(6):779–91. doi: 10.1016/s0092-8674(03)00193-4. PMID: 12654245.; Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature. 2002 Apr 11;416(6881):648–53. doi: 10.1038/nature737. PMID: 11923872.; Parisi T, Pollice A, Cristofano AD, Calabrò V, Mantia GL. Transcriptional Regulation of the Human Tumor Suppressor p14ARF by E2F1, E2F2, E2F3, and Sp1-like Factors. Biochemical and Biophysical Research Communications. 2002 Mar;291(5):1138–45. doi: 10.1006/bbrc.2002.6591.; Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 1998 Mar 20;92(6):725–34. doi: 10.1016/s0092-8674(00)81401-4. PMID: 9529249.; Jeffrey PD, Gorina S, Pavletich NP. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science. 1995 Mar 10;267(5203):1498–502. doi: 10.1126/science.7878469. PMID: 7878469.; Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 1993 Jul;7(7A):1126–32. doi: 10.1101/gad.7.7a.1126. PMID: 8319905.