DNA Damage/Telomere Stress Induced Senescence
Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G. Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence. Molecular and Cellular Biology. 2009 Aug 01;29(16):4495–507. doi: 10.1128/mcb.01868-08.; Wu Y, Xiao S, Zhu X. MRE11–RAD50–NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nature Structural & Molecular Biology. 2007 Aug 12;14(9):832–40. doi: 10.1038/nsmb1286.; de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005 Sep 15;19(18):2100–10. doi: 10.1101/gad.1346005. PMID: 16166375.; Lee JH, Paull TT. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science. 2005 Apr 22;308(5721):551–4. doi: 10.1126/science.1108297. PMID: 15790808.; Zhang H, Cohen SN. Smurf2 up-regulation activates telomere-dependent senescence. Genes Dev. 2004 Dec 15;18(24):3028–40. PMID: 15574587; PMCID: PMC535914.; Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T. Control of Human Telomere Length by TRF1 and TRF2. Molecular and Cellular Biology. 2000 Mar 01;20(5):1659–68. doi: 10.1128/mcb.20.5.1659-1668.2000.; Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 1999 Feb 26;283(5406):1321–5. doi: 10.1126/science.283.5406.1321. PMID: 10037601.; Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet. 1998 Dec;20(4):398–400. doi: 10.1038/3882. PMID: 9843217.; Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 1998 Sep 11;281(5383):1674–7. doi: 10.1126/science.281.5383.1674. PMID: 9733514.; Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 1998 Sep 11;281(5383):1677–9. doi: 10.1126/science.281.5383.1677. PMID: 9733515.; Yu T, Anderson D. Reactive oxygen species-induced DNA damage and its modification: A chemical investigation. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1997 Oct;379(2):201–10. doi: 10.1016/s0027-5107(97)00141-3.; Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993 Nov 19;75(4):805–16. doi: 10.1016/0092-8674(93)90499-g. PMID: 8242751.; el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817–25. doi: 10.1016/0092-8674(93)90500-p. PMID: 8242752.; Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 1990 Aug 30;346(6287):866–8. doi: 10.1038/346866a0. PMID: 2392154.; Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990 May 31;345(6274):458–60. doi: 10.1038/345458a0. PMID: 2342578.