Negative regulation of NOTCH4 signaling
Ramakrishnan G, Davaakhuu G, Chung WC, Zhu H, Rana A, Filipovic A, Green AR, Atfi A, Pannuti A, Miele L, Tzivion G. AKT and 14-3-3 Regulate Notch4 Nuclear Localization. Scientific Reports. 2015 Mar 05;5(1):8782. doi: 10.1038/srep08782.; Cummins TD, Mendenhall MD, Lowry MN, A.Korte E, Barati MT, Khundmiri SJ, Salyer SA, Klein JB, Powell DW. Elongin C is a mediator of Notch4 activity in human renal tubule cells. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2011 Dec;1814(12):1748–57. doi: 10.1016/j.bbapap.2011.09.010.; Sun Y, Klauzinska M, Lake RJ, Lee JM, Santopietro S, Raafat A, Salomon D, Callahan R, Artavanis-Tsakonas S. Trp53 regulates Notch 4 signaling through Mdm2. J Cell Sci. 2011 Apr 01;124(Pt 7):1067–76. PMID: 21402876; PMCID: PMC3056605.; Bargo S, Raafat A, McCurdy D, Amirjazil I, Shu Y, Traicoff J, Plant J, Vonderhaar BK, Callahan R. Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Biochemical and Biophysical Research Communications. 2010 Oct;400(4):606–12. doi: 10.1016/j.bbrc.2010.08.111.; Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI. Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development. Journal of Biological Chemistry. 2004 Mar;279(10):9417–23. doi: 10.1074/jbc.m312337200.; Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J. SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation. Molecular and Cellular Biology. 2001 Nov 01;21(21):7403–15. doi: 10.1128/mcb.21.21.7403-7415.2001.