Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JHJ. Understanding nucleotide excision repair and its roles in cancer and ageing. Nature Reviews Molecular Cell Biology. 2014 Jun 23;15(7):465–81. doi: 10.1038/nrm3822.; Vermeulen W, Fousteri M. Mammalian Transcription-Coupled Excision Repair. Cold Spring Harbor Perspectives in Biology. 2013 Aug 01;5(8):a012625. doi: 10.1101/cshperspect.a012625.; Hanawalt PC, Spivak G. Transcription-coupled DNA repair: two decades of progress and surprises. Nature Reviews Molecular Cell Biology. 2008 Dec;9(12):958–70. doi: 10.1038/nrm2549.; Svejstrup JQ. Mechanisms of transcription-coupled DNA repair. Nature Reviews Molecular Cell Biology. 2002 Jan;3(1):21–9. doi: 10.1038/nrm703.; Mellon I, Bohr VA, Smith CA, Hanawalt PC. Preferential DNA repair of an active gene in human cells. Proc. Natl. Acad. Sci. U.S.A. 1986 Dec;83(23):8878–82. doi: 10.1073/pnas.83.23.8878.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.1.-.- | |||
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.3.2.32 | cullin-RING-type E3 NEDD8 transferase | [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine:[cullin] [NEDD8-protein] transferase (isopeptide bond-forming; RING-type) | |
| 2.7.11.22 | cyclin-dependent kinase | ATP:cyclin phosphotransferase | |
| 2.7.11.23 | [RNA-polymerase]-subunit kinase | ATP:[DNA-directed RNA polymerase] phosphotransferase | |
| 2.7.7.48 | RNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed) | |
| 2.7.7.6 | DNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 | ||
| 3.6.4.13 | RNA helicase | ||
| 5.2.1.8 | peptidylprolyl isomerase | Peptidylproline cis-trans-isomerase | |
| 5.6.2.3 | DNA 5'-3' helicase | DNA 5'-3' helicase (ATP-hydrolysing) | |
| 5.6.2.4 | DNA 3'-5' helicase | DNA 3'-5' helicase (ATP-hydrolysing) |
Proteins
| Protein ID | name | full name |
|---|