Biosynthesis of Lipoxins (LX)

Stsiapanava A, Samuelsson B, Haeggström JZ. Capturing LTA 4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB 4 synthesis. Proc. Natl. Acad. Sci. U.S.A. 2017 Aug 21;114(36):9689–94. doi: 10.1073/pnas.1710850114.; Buczynski MW, Dumlao DS, Dennis EA. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. Journal of Lipid Research. 2009 Jun;50(6):1015–38. doi: 10.1194/jlr.r900004-jlr200.; Chiang N, Serhan CN, Dahlén SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, Brink C. The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev. 2006 Sep;58(3):463–87. doi: 10.1124/pr.58.3.4. PMID: 16968948.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

lipoxin B4(1-)

Formula: C20H31O5 (351.2171376)

CAS ID: 98049-69-5

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase
1.1.1.232 15-hydroxyicosatetraenoate dehydrogenase (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase
1.13.11.31 arachidonate 12-lipoxygenase arachidonate:oxygen 12-oxidoreductase
1.13.11.33 arachidonate 15-lipoxygenase arachidonate:oxygen 15-oxidoreductase
1.13.11.34 arachidonate 5-lipoxygenase arachidonate:oxygen 5-oxidoreductase
1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase 11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase
1.3.1.74 2-alkenal reductase [NAD(P)+] n-alkanal:NAD(P)+ 2-oxidoreductase
4.4.1.20 leukotriene-C4 synthase leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)


Proteins

Protein ID name full name