Regulation of APC/C activators between G1/S and early anaphase

Buschhorn BA, Peters JM. How APC/C orders destruction. Nat Cell Biol. 2006 Mar;8(3):209–11. doi: 10.1038/ncb0306-209. PMID: 16508672.; Castro A, Bernis C, Vigneron S, Labbé JC, Lorca T. The anaphase-promoting complex: a key factor in the regulation of cell cycle. Oncogene. 2005 Jan 13;24(3):314–25. doi: 10.1038/sj.onc.1207973. PMID: 15678131.; Harper JW, Burton JL, Solomon MJ. The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev. 2002 Sep 01;16(17):2179–206. doi: 10.1101/gad.1013102. PMID: 12208841.; Peters JM. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell. 2002 May;9(5):931–43. doi: 10.1016/s1097-2765(02)00540-3. PMID: 12049731.; Zachariae W, Nasmyth K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 1999 Aug 15;13(16):2039–58. doi: 10.1101/gad.13.16.2039. PMID: 10465783.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase


Proteins

Protein ID name full name