Oxidative Stress Induced Senescence
Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D. PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes. Molecular Cell. 2012 Feb;45(3):344–56. doi: 10.1016/j.molcel.2012.01.002.; Lin TY, Cheng YC, Yang HC, Lin WC, Wang CC, Lai PL, Shieh SY. Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. Oncogene. 2012 Jul 05;31(27):3287–97. doi: 10.1038/onc.2011.491. PMID: 22020331.; Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G. Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence. Molecular and Cellular Biology. 2009 Aug 01;29(16):4495–507. doi: 10.1128/mcb.01868-08.; Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M. Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence. PLoS ONE. 2009 May 20;4(5):e5622. doi: 10.1371/journal.pone.0005622.; Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 2009 May 15;23(10):1171–6. PMID: 19451217; PMCID: PMC2685535.; Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009 May 15;23(10):1177–82. PMID: 19451218; PMCID: PMC2685533.; White A, Pargellis CA, Studts JM, Werneburg BG, Farmer BT. Molecular basis of MAPK-activated protein kinase 2:p38 assembly. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6353–8. PMID: 17395714; PMCID: PMC1851067.; Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J. 2007 Mar 21;26(6):1637–48. PMID: 17332741; PMCID: PMC1829390.; Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007 Mar 01;21(5):525–30. PMID: 17344414; PMCID: PMC1820894.; Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, Wright PE, Han J. PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007 Jan 26;128(2):295–308. doi: 10.1016/j.cell.2006.11.050. PMID: 17254968.; Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene. Genes Dev. 2007 Jan 01;21(1):49–54. doi: 10.1101/gad.1499407.; Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, Ferbeyre G. DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell. 2006 Apr;17(4):1583–92. PMID: 16436515; PMCID: PMC1415317.; Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell. 2005 Dec 09;20(5):673–85. doi: 10.1016/j.molcel.2005.10.038. PMID: 16337592.; Takekawa M, Tatebayashi K, Saito H. Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. Mol Cell. 2005 Apr 29;18(3):295–306. doi: 10.1016/j.molcel.2005.04.001. PMID: 15866172.; Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR. MAPKAP Kinase 3pK Phosphorylates and Regulates Chromatin Association of the Polycomb Group Protein Bmi1. Journal of Biological Chemistry. 2005 Feb;280(7):5178–87. doi: 10.1074/jbc.m407155200.; Lukas SM, Kroe RR, Wildeson J, Peet GW, Frego L, Davidson W, Ingraham RH, Pargellis CA, Labadia ME, Werneburg BG. Catalysis and function of the p38 alpha.MK2a signaling complex. Biochemistry. 2004 Aug 10;43(31):9950–60. doi: 10.1021/bi049508v. PMID: 15287722.; Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 2003 Oct 15;22(20):5323–35. PMID: 14532106; PMCID: PMC213796.; New L, Jiang Y, Han J. Regulation of PRAK subcellular location by p38 MAP kinases. Mol Biol Cell. 2003 Jun;14(6):2603–16. PMID: 12808055; PMCID: PMC194907.; Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002 Nov 15;16(22):2893–905. PMID: 12435631; PMCID: PMC187479.; Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. J Biol Chem. 2002 Oct 25;277(43):40703–9. doi: 10.1074/jbc.m202004200. PMID: 12189133.; Meng W, Swenson LL, Fitzgibbon MJ, Hayakawa K, ter Haar E, Behrens AE, Fulghum JR, Lippke JA. Structure of Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Suggests a Bifunctional Switch That Couples Kinase Activation with Nuclear Export. Journal of Biological Chemistry. 2002 Oct;277(40):37401–5. doi: 10.1074/jbc.c200418200.; Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J. Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol. 2002 Aug;4(8):556–64. doi: 10.1038/ncb822. PMID: 12134156.; Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ. Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters. Molecular and Cellular Biology. 2001 Oct 01;21(20):6820–32. doi: 10.1128/mcb.21.20.6820-6832.2001.; Fleming Y, Armstrong CG, Morrice N, Paterson A, Goedert M, Cohen P. Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Biochem J. 2000 Nov 15;352 Pt 1():145–54. PMID: 11062067; PMCID: PMC1221441.; New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 1998 Jun 15;17(12):3372–84. PMID: 9628874; PMCID: PMC1170675.; Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 1998 May 01;17(9):2596–606. PMID: 9564042; PMCID: PMC1170601.; Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 1998 Mar 20;92(6):725–34. doi: 10.1016/s0092-8674(00)81401-4. PMID: 9529249.; Mizukami Y, Yoshioka K, Morimoto S, Yoshida Ki. A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion. J Biol Chem. 1997 Jun 27;272(26):16657–62. doi: 10.1074/jbc.272.26.16657. PMID: 9195981.; Deacon K, Blank JL. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J Biol Chem. 1997 May 30;272(22):14489–96. doi: 10.1074/jbc.272.22.14489. PMID: 9162092.; Ainbinder E, Bergelson S, Pinkus R, Daniel V. Regulatory Mechanisms Involved in Activator-Protein-1 (AP-1)-Mediated Activation of Glutathione-S-Transferase Gene Expression by Chemical Agents. European Journal of Biochemistry. 1997 Jan;243(1-2):49–57. doi: 10.1111/j.1432-1033.1997.0049a.x.; Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 1997 Jan 03;275(5296):90–4. doi: 10.1126/science.275.5296.90. PMID: 8974401.; Clifton AD, Young PR, Cohen P. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett. 1996 Sep 02;392(3):209–14. doi: 10.1016/0014-5793(96)00816-2. PMID: 8774846.; McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR. Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase. Journal of Biological Chemistry. 1996 Apr;271(14):8488–92. doi: 10.1074/jbc.271.14.8488.; Raingeaud J, Whitmarsh AJ, Barrett T, Dérijard B, Davis RJ. MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway. Molecular and Cellular Biology. 1996 Mar 01;16(3):1247–55. doi: 10.1128/mcb.16.3.1247.; Sithanandam G, Latif F, Duh F, Bernal R, Smola U, Li H, Kuzmin I, Wixler V, Geil L, Shrestha S, Lloyd PA, Bader S, Sekido Y, Tartof KD, Kashuba VI, Zabarovsky ER, Dean M, Klein G, Lerman MI, Minna JD, Rapp UR, Allikmets R. 3pK, a New Mitogen-Activated Protein Kinase-Activated Protein Kinase Located in the Small Cell Lung Cancer Tumor Suppressor Gene Region. Molecular and Cellular Biology. 1996 Mar 01;16(3):868–76. doi: 10.1128/mcb.16.3.868.; Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. The EMBO Journal. 1995 Dec;14(23):5920–30. doi: 10.1002/j.1460-2075.1995.tb00280.x.; Okazaki K, Sagata N. The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. The EMBO Journal. 1995 Oct;14(20):5048–59. doi: 10.1002/j.1460-2075.1995.tb00187.x.; Glover JN, Harrison SC. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature. 1995 Jan 19;373(6511):257–61. doi: 10.1038/373257a0. PMID: 7816143.; Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993 Dec 16;366(6456):704–7. doi: 10.1038/366704a0. PMID: 8259215.