WNT mediated activation of DVL
Kikuchi A, Yamamoto H, Sato A, Matsumoto S. New insights into the mechanism of Wnt signaling pathway activation. Int Rev Cell Mol Biol. 2011;291():21–71. doi: 10.1016/b978-0-12-386035-4.00002-1. PMID: 22017973.; Gao C, Chen YG. Dishevelled: The hub of Wnt signaling. Cell Signal. 2010 May;22(5):717–27. doi: 10.1016/j.cellsig.2009.11.021. PMID: 20006983.; Qin Y, Li L, Pan W, Wu D. Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl. Journal of Biological Chemistry. 2009 Aug;284(34):22544–8. doi: 10.1074/jbc.m109.014399.; Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science. 2008 Sep 05;321(5894):1350–3. PMID: 18772438; PMCID: PMC2532521.; Lee Y, Gao Y, Wang H. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cellular Signalling. 2008 Feb;20(2):443–52. doi: 10.1016/j.cellsig.2007.11.005.; Schwarz-Romond T, Fiedler M, Shibata N, Butler PJG, Kikuchi A, Higuchi Y, Bienz M. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nature Structural & Molecular Biology. 2007 May 27;14(6):484–92. doi: 10.1038/nsmb1247.; Ossipova O, Dhawan S, Sokol S, Green JB. Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev Cell. 2005 Jun;8(6):829–41. doi: 10.1016/j.devcel.2005.04.011. PMID: 15935773.; Cong F, Schweizer L, Varmus H. Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development. 2004 Oct;131(20):5103–15. doi: 10.1242/dev.01318. PMID: 15459103.; Wong H, Bourdelas A, Krauss A, Lee H, Shao Y, Wu D, Mlodzik M, Shi D, Zheng J. Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled. Molecular Cell. 2003 Nov;12(5):1251–60. doi: 10.1016/s1097-2765(03)00427-1.; Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol. 2001 Jul;3(7):628–36. doi: 10.1038/35083016. PMID: 11433294.; Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell. 2001 Apr;7(4):801–9. doi: 10.1016/s1097-2765(01)00224-6. PMID: 11336703.; Umbhauer M, Djiane A, Goisset C, Penzo-Méndez A, Riou JF, Boucaut JC, Shi DL. The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J. 2000 Sep 15;19(18):4944–54. PMID: 10990458; PMCID: PMC314225.; Willert K, Brink M, Wodarz A, Varmus H, Nusse R. Casein kinase 2 associates with and phosphorylates dishevelled. EMBO J. 1997 Jun 02;16(11):3089–96. PMID: 9214626; PMCID: PMC1169927.