MyD88-independent TLR4 cascade

Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K. Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochemical and Biophysical Research Communications. 2008 Mar;368(1):94–9. doi: 10.1016/j.bbrc.2008.01.061.; Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 2008 Apr;9(4):361–8. PMID: 18297073; PMCID: PMC4112825.; Gangloff M, Gay NJ. MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci. 2004 Jun;29(6):294–300. doi: 10.1016/j.tibs.2004.04.008. PMID: 15276183.; Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Nov;4(11):1144–50. doi: 10.1038/ni986. PMID: 14556004.; Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003 Aug 01;301(5633):640–3. doi: 10.1126/science.1087262. PMID: 12855817.; Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol. 2003 Feb;4(2):161–7. doi: 10.1038/ni886. PMID: 12539043.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase


Proteins

Protein ID name full name