Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Kim Y, Kang K, Kim I, Lee YJ, Oh C, Ryoo J, Jeong E, Ahn K. Molecular mechanisms of MHC class I-antigen processing: redox considerations. Antioxid Redox Signal. 2009 Apr;11(4):907–36. doi: 10.1089/ars.2008.2316. PMID: 19178136.; Wearsch PA, Cresswell P. The quality control of MHC class I peptide loading. Current Opinion in Cell Biology. 2008 Dec;20(6):624–31. doi: 10.1016/j.ceb.2008.09.005.; Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol. 2008 Aug;8(8):607–18. PMID: 18641646; PMCID: PMC2735460.; Rock KL, York IA, Goldberg AL. Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol. 2004 Jul;5(7):670–7. doi: 10.1038/ni1089. PMID: 15224092.; Antoniou AN, Powis SJ, Elliott T. Assembly and export of MHC class I peptide ligands. Curr Opin Immunol. 2003 Feb;15(1):75–81. doi: 10.1016/s0952-7915(02)00010-9. PMID: 12495737.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name