Nucleotide metabolism
Welin M, Nordlund P. Understanding specificity in metabolic pathways—Structural biology of human nucleotide metabolism. Biochemical and Biophysical Research Communications. 2010 May;396(1):157–63. doi: 10.1016/j.bbrc.2010.04.054.; Hyde JE. Targeting purine and pyrimidine metabolism in human apicomplexan parasites. Curr Drug Targets. 2007 Jan;8(1):31–47. PMID: 17266529; PMCID: PMC2720675.; Rudolph FB. The biochemistry and physiology of nucleotides. J Nutr. 1994 Jan;124(1 Suppl):124S–127S. doi: 10.1093/jn/124.suppl_1.124s. PMID: 8283301.
Metabolites
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
Formula: C9H13N4O8P (336.0470988)
CAS ID:
beta-D-fructofuranose 1,6-bisphosphate(4-)
Formula: C6H10O12P2 (335.96475200000003)
CAS ID: 488-69-7
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.1.5.- | |||
| 1.1.1.205 | IMP dehydrogenase | IMP:NAD+ oxidoreductase | |
| 1.17.4.1 | ribonucleoside-diphosphate reductase | 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase | |
| 1.3.1.2 | dihydropyrimidine dehydrogenase (NADP+) | 5,6-dihydrouracil:NADP+ 5-oxidoreductase | |
| 2.7.1.48 | uridine/cytidine kinase | ATP:uridine/cytidine 5'-phosphotransferase | |
| 2.7.4.14 | UMP/CMP kinase | ATP:CMP(UMP) phosphotransferase | |
| 2.7.4.3 | adenylate kinase | ATP:AMP phosphotransferase | |
| 2.7.4.6 | nucleoside-diphosphate kinase | ATP:nucleoside-diphosphate phosphotransferase | |
| 2.7.4.9 | dTMP kinase | ATP:dTMP phosphotransferase | |
| 3.1.3.5 | 5'-nucleotidase | 5'-ribonucleotide phosphohydrolase | |
| 3.5.4.4 | adenosine deaminase | adenosine aminohydrolase | |
| 3.6.1.13 | ADP-ribose diphosphatase | ADP-D-ribose ribophosphohydrolase | |
| 3.6.1.16 | CDP-glycerol diphosphatase | CDP-glycerol phosphoglycerohydrolase | |
| 3.6.1.53 | Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase | CDP-choline phosphohydrolase | |
| 3.6.1.56 | 2-hydroxy-dATP diphosphatase | 2-hydroxy-dATP diphosphohydrolase | |
| 3.6.1.58 | 8-oxo-dGDP phosphatase | 8-oxo-dGDP phosphohydrolase | |
| 3.6.1.66 | XTP/dITP diphosphatase | XTP/dITP diphosphohydrolase (diphosphate-forming) | |
| 3.6.1.68 | geranyl diphosphate phosphohydrolase | geranyl-diphosphate phosphohydrolase | |
| 3.6.1.76 | prenyl-diphosphate phosphatase | prenyl diphosphate/3-methylbut-3-en-1-yl diphosphate phosphohydrolase | |
| 6.3.4.2 | CTP synthase (glutamine hydrolysing) | UTP:ammonia ligase (ADP-forming) |
Proteins
| Protein ID | name | full name |
|---|