Signal transduction by L1

Maness PF, Schachner M. Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration. Nat Neurosci. 2007 Jan;10(1):19–26. doi: 10.1038/nn1827. PMID: 17189949.; Whittard JD, Sakurai T, Cassella MR, Gazdoiu M, Felsenfeld DP. MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth. Mol Biol Cell. 2006 Jun;17(6):2696–706. PMID: 16597699; PMCID: PMC1474804.; Schmid RS, Midkiff BR, Kedar VP, Maness PF. Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling. Neuroreport. 2004 Dec 22;15(18):2791–4. PMID: 15597056.; Buhusi M, Midkiff BR, Gates AM, Richter M, Schachner M, Maness PF. Close Homolog of L1 Is an Enhancer of Integrin-mediated Cell Migration. Journal of Biological Chemistry. 2003 Jul;278(27):25024–31. doi: 10.1074/jbc.m303084200.; Schmid R, Pruitt WM, Maness PF. A MAP Kinase-Signaling Pathway Mediates Neurite Outgrowth on L1 and Requires Src-Dependent Endocytosis. J. Neurosci. 2000 Jun 01;20(11):4177–88. doi: 10.1523/jneurosci.20-11-04177.2000.; Schaefer AW, Kamiguchi H, Wong EV, Beach CM, Landreth G, Lemmon V. Activation of the MAPK Signal Cascade by the Neural Cell Adhesion Molecule L1 Requires L1 Internalization. Journal of Biological Chemistry. 1999 Dec;274(53):37965–73. doi: 10.1074/jbc.274.53.37965.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name