Signaling by NTRKs

Marlin MC, Li G. Biogenesis and function of the NGF/TrkA signaling endosome. Int Rev Cell Mol Biol. 2015;314():239–57. PMID: 25619719; PMCID: PMC4307610.; Ichim G, Genevois AL, Ménard M, Yu LY, Coelho-Aguiar JM, Llambi F, Jarrosson-Wuilleme L, Lefebvre J, Tulasne D, Dupin E, Le Douarin N, Arumäe U, Tauszig-Delamasure S, Mehlen P. The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment. Mol Cell. 2013 Sep 12;51(5):632–46. doi: 10.1016/j.molcel.2013.08.021. PMID: 24034695.; Park H, Poo MM. Neurotrophin regulation of neural circuit development and function. Nat Rev Neurosci. 2013 Jan;14(1):7–23. doi: 10.1038/nrn3379. PMID: 23254191.; Skaper SD. The neurotrophin family of neurotrophic factors: an overview. Methods Mol Biol. 2012;846():1–12. doi: 10.1007/978-1-61779-536-7_1. PMID: 22367796.; Minichiello L. TrkB signalling pathways in LTP and learning. Nat Rev Neurosci. 2009 Dec;10(12):850–60. doi: 10.1038/nrn2738. PMID: 19927149.; Tauszig-Delamasure S, Yu LY, Cabrera JR, Bouzas-Rodriguez J, Mermet-Bouvier C, Guix C, Bordeaux MC, Arumäe U, Mehlen P. The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13361–6. PMID: 17686986; PMCID: PMC1948910.; Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat Rev Neurosci. 2005 Aug;6(8):603–14. doi: 10.1038/nrn1726. PMID: 16062169.; Lessmann V, Gottmann K, Malcangio M. Neurotrophin secretion: current facts and future prospects. Prog Neurobiol. 2003 Apr;69(5):341–74. doi: 10.1016/s0301-0082(03)00019-4. PMID: 12787574.; Chao MV. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci. 2003 Apr;4(4):299–309. doi: 10.1038/nrn1078. PMID: 12671646.; Poo MM. Neurotrophins as synaptic modulators. Nat Rev Neurosci. 2001 Jan;2(1):24–32. doi: 10.1038/35049004. PMID: 11253356.; Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 2000 Dec 01;14(23):2919–37. doi: 10.1101/gad.841400. PMID: 11114882.; Rogalski SL, Appleyard SM, Pattillo A, Terman GW, Chavkin C. TrkB Activation by Brain-derived Neurotrophic Factor Inhibits the G Protein-gated Inward Rectifier Kir3 by Tyrosine Phosphorylation of the Channel. Journal of Biological Chemistry. 2000 Aug;275(33):25082–8. doi: 10.1074/jbc.m000183200.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name