Toll Like Receptor 5 (TLR5) Cascade
Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol. 2001 Aug 15;167(4):1882–5. doi: 10.4049/jimmunol.167.4.1882. PMID: 11489966.; Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099–103. doi: 10.1038/35074106. PMID: 11323673.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.3.2.23 | E2 ubiquitin-conjugating enzyme | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase | |
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 2.7.11.10 | IkappaB kinase | ATP:[IkappaB protein] phosphotransferase | |
| 2.7.11.22 | cyclin-dependent kinase | ATP:cyclin phosphotransferase | |
| 2.7.11.24 | mitogen-activated protein kinase | ATP:protein phosphotransferase (MAPKK-activated) | |
| 2.7.11.25 | mitogen-activated protein kinase kinase kinase | ATP:protein phosphotransferase (MAPKKKK-activated) | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 |
Proteins
| Protein ID | name | full name |
|---|