AURKA Activation by TPX2

Dodson CA, Bayliss R. Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic. Journal of Biological Chemistry. 2012 Jan;287(2):1150–7. doi: 10.1074/jbc.m111.312090.; Xu X, Wang X, Xiao Z, Li Y, Wang Y. Two TPX2-Dependent Switches Control the Activity of Aurora A. PLoS ONE. 2011 Feb 09;6(2):e16757. doi: 10.1371/journal.pone.0016757.; Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G. Control of Aurora-A stability through interaction with TPX2. J Cell Sci. 2011 Jan 01;124(Pt 1):113–22. PMID: 21147853; PMCID: PMC3001410.; Bayliss R, Sardon T, Vernos I, Conti E. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell. 2003 Oct;12(4):851–62. doi: 10.1016/s1097-2765(03)00392-7. PMID: 14580337.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.6.5.-
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)


Proteins

Protein ID name full name