Methionine salvage pathway

Albers E. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. IUBMB Life. 2009 Dec;61(12):1132–42. doi: 10.1002/iub.278. PMID: 19946895.; Pirkov I, Norbeck J, Gustafsson L, Albers E. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. FEBS J. 2008 Aug;275(16):4111–20. doi: 10.1111/j.1742-4658.2008.06552.x. PMID: 18625006.

Metabolites

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

Formula: C6H10O3S (162.035063)

CAS ID: 746507-19-7

5'-Methylthioadenosine

Formula: C11H15N5O3S (297.089556)

CAS ID: 2457-80-9

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-)

Formula: C6H11O7PS (257.9963106)

CAS ID:

S-methyl-5-thio-D-ribulose 1-phosphate(2-)

Formula: C6H11O7PS (257.9963106)

CAS ID:



Enzyme

EC Number name full name note
3.1.3.77 acireductone synthase 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)
5.3.1.23 S-methyl-5-thioribose-1-phosphate isomerase S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase


Proteins

Protein ID name full name