Factors involved in megakaryocyte development and platelet production

Goldfarb AN. Transcriptional control of megakaryocyte development. Oncogene. 2007 Oct 15;26(47):6795–802. doi: 10.1038/sj.onc.1210762. PMID: 17934486.; Yun-Hua C, Bluteau D, Debili N, Vainchenker W. FROM HEMATOPOIETIC STEM CELLS TO PLATELETS. Journal of Thrombosis and Haemostasis. 2007 Jul;5():SOA–S. doi: 10.1111/j.1538-7836.2007.tb00815.x.; Deutsch VR, Tomer A. Megakaryocyte development and platelet production. Br J Haematol. 2006 Sep;134(5):453–66. doi: 10.1111/j.1365-2141.2006.06215.x. PMID: 16856888.; Richardson JL, Shivdasani RA, Boers C, Hartwig JH, Italiano JE. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15;106(13):4066–75. PMID: 16118320; PMCID: PMC1895242.; Kaushansky K. The molecular mechanisms that control thrombopoiesis. Journal of Clinical Investigation. 2005 Dec 01;115(12):3339–47. doi: 10.1172/jci26674.; Metcalf D, Carpinelli MR, Hyland C, Mifsud S, Dirago L, Nicola NA, Hilton DJ, Alexander WS. Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood. 2005 May 01;105(9):3480–7. doi: 10.1182/blood-2004-12-4806. PMID: 15665109.; Schulze H, Shivdasani RA. Molecular mechanisms of megakaryocyte differentiation. Semin Thromb Hemost. 2004 Aug;30(4):389–98. doi: 10.1055/s-2004-833474. PMID: 15354260.; Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, Shido K, Jin DK, Dias S, Zhang F, Hartman TE, Hackett NR, Crystal RG, Witte L, Hicklin DJ, Bohlen P, Eaton D, Lyden D, de Sauvage F, Rafii S. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med. 2004 Jan;10(1):64–71. doi: 10.1038/nm973. PMID: 14702636.; Kaushansky K. Thrombopoietin: a tool for understanding thrombopoiesis. Journal of Thrombosis and Haemostasis. 2003 Jul;1(7):1587–92. doi: 10.1046/j.1538-7836.2003.00273.x.; Shiraga M, Ritchie A, Aidoudi S, Baron V, Wilcox D, White G, Ybarrondo B, Murphy G, Leavitt A, Shattil S. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999 Dec 27;147(7):1419–30. PMID: 10613901; PMCID: PMC2174239.

Metabolites



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name