Energy dependent regulation of mTOR by LKB1-AMPK

Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nature Reviews Molecular Cell Biology. 2007 Oct;8(10):774–85. doi: 10.1038/nrm2249.; Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007 Jul;12(1):9–22. doi: 10.1016/j.ccr.2007.05.008. PMID: 17613433.; Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, Mäkelä TP. The LKB1 tumor suppressor kinase in human disease. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2007 Jan;1775(1):63–75. doi: 10.1016/j.bbcan.2006.08.003.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase


Proteins

Protein ID name full name