Signaling by VEGF

Matsumoto T, Mugishima H. Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis. J Atheroscler Thromb. 2006 Jun;13(3):130–5. doi: 10.5551/jat.13.130. PMID: 16835467.; Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 2006 May;7(5):359–71. doi: 10.1038/nrm1911. PMID: 16633338.; Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res. 2006 Mar 10;312(5):549–60. doi: 10.1016/j.yexcr.2005.11.012. PMID: 16336962.; Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005 Feb 10;23(5):1011–27. doi: 10.1200/jco.2005.06.081. PMID: 15585754.; Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L. VEGF-receptor signal transduction. Trends Biochem Sci. 2003 Sep;28(9):488–94. doi: 10.1016/s0968-0004(03)00193-2. PMID: 13678960.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nitric oxide

Formula: NO (29.997989)

CAS ID: 10102-43-9

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

L-argininium(1+)

Formula: C6H15N4O2 (175.119495)

CAS ID: 17806-42-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.6.2.4 NADPH-hemoprotein reductase NADPH:hemoprotein oxidoreductase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name
P36587 ccr1 NADPH--cytochrome P450 reductase
Q12701 ksg1 Serine/threonine-protein kinase ksg1
Q9Y7K2 tor2 Serine/threonine-protein kinase tor2