Cellular Senescence

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 06;153(6):1194–217. PMID: 23746838; PMCID: PMC3836174.; Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011 Nov 02;479(7372):232–6. PMID: 22048312; PMCID: PMC3468323.; Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence: Figure 1. Genes Dev. 2010 Nov 15;24(22):2463–79. doi: 10.1101/gad.1971610.; Adams PD. Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell. 2009 Oct 09;36(1):2–14. doi: 10.1016/j.molcel.2009.09.021. PMID: 19818705.; Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009 Aug;11(8):973–9. PMID: 19597488; PMCID: PMC2743561.; Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008 Dec 02;6(12):2853–68. PMID: 19053174; PMCID: PMC2592359.; Fridman AL, Tainsky MA. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene. 2008 Oct 09;27(46):5975–87. PMID: 18711403; PMCID: PMC3843241.; Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008 Jun 13;133(6):1006–18. doi: 10.1016/j.cell.2008.03.038. PMID: 18555777.; Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell. 2008 Jun 13;133(6):1019–31. doi: 10.1016/j.cell.2008.03.039. PMID: 18555778.; Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nature Reviews Molecular Cell Biology. 2007 Sep;8(9):729–40. doi: 10.1038/nrm2233.; Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007 Jul 27;130(2):223–33. doi: 10.1016/j.cell.2007.07.003. PMID: 17662938.; Campisi J. The biology of replicative senescence. Eur J Cancer. 1997 Apr;33(5):703–9. doi: 10.1016/s0959-8049(96)00058-5. PMID: 9282108.; HAYFLICK L, MOORHEAD PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961 Dec;25():585–621. doi: 10.1016/0014-4827(61)90192-6. PMID: 13905658.

Metabolites

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.-.-
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)


Proteins

Protein ID name full name
P04551 cdc2 Cyclin-dependent kinase 1
P28829 byr2 Protein kinase byr2
Q09683 rad32 Double-strand break repair protein rad32
Q12706 psk1 Serine/threonine-protein kinase psk1
Q92398 spm1 Mitogen-activated protein kinase spm1
Q9UTJ8 rad50 DNA repair protein rad50