G2/M Transition

Fisher D, Krasinska L, Coudreuse D, Novák B. Phosphorylation network dynamics in the control of cell cycle transitions. J Cell Sci. 2012 Oct 15;125(Pt 20):4703–11. doi: 10.1242/jcs.106351. PMID: 23223895.; Salaun P, Rannou Y, Prigent C. Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards. Adv Exp Med Biol. 2008;617():41–56. PMID: 18497029; PMCID: PMC2533106.; Nilsson I, Hoffmann I. Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res. 2000;4():107–14. doi: 10.1007/978-1-4615-4253-7_10. PMID: 10740819.; Nigg EA. Polo-like kinases: positive regulators of cell division from start to finish. Curr Opin Cell Biol. 1998 Dec;10(6):776–83. doi: 10.1016/s0955-0674(98)80121-x. PMID: 9914175.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Methanol

Formula: CH4O (32.0262134)

CAS ID: 67-56-1

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.21 polo kinase ATP:protein phosphotransferase (spindle-pole-dependent)
3.1.1.89 protein phosphatase methylesterase-1 [phosphatase 2A protein]-leucine ester acylhydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name
O59790 ark1 Aurora kinase
P06652 cdc25 M-phase inducer phosphatase
P50528 plo1 Serine/threonine-protein kinase plo1
Q9P7D2 ppe1 Protein phosphatase methylesterase 1