Costimulation by the CD28 family
Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nature Reviews Immunology. 2013 Mar 08;13(4):227–42. doi: 10.1038/nri3405.; Acuto O, Michel F. CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat Rev Immunol. 2003 Dec;3(12):939–51. doi: 10.1038/nri1248. PMID: 14647476.; Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nat Rev Immunol. 2002 Feb;2(2):116–26. doi: 10.1038/nri727. PMID: 11910893.; Alegre ML, Frauwirth KA, Thompson CB. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol. 2001 Dec;1(3):220–8. doi: 10.1038/35105024. PMID: 11905831.; Slavik JM, Hutchcroft JE, Bierer BE. CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 1999;19(1):1–24. doi: 10.1007/bf02786473. PMID: 10374692.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P50527 | shk1 | Serine/threonine-protein kinase shk1/pak1 |
| Q12701 | ksg1 | Serine/threonine-protein kinase ksg1 |
| Q9Y7K2 | tor2 | Serine/threonine-protein kinase tor2 |