Transport and metabolism of PAPS

Faiyaz ul Haque M, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH. Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse. Nat Genet. 1998 Oct;20(2):157–62. doi: 10.1038/2458. PMID: 9771708.; Venkatachalam KV, Akita H, Strott CA. Molecular Cloning, Expression, and Characterization of Human Bifunctional 3'-Phosphoadenosine 5'-Phosphosulfate Synthase and Its Functional Domains. Journal of Biological Chemistry. 1998 Jul;273(30):19311–20. doi: 10.1074/jbc.273.30.19311.; Girard J, Baekkevold ES, Amalric F. Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase 1. The FASEB Journal. 1998 May;12(7):603–12. doi: 10.1096/fasebj.12.7.603.; Robbins PW, Lipmann F. Separation of the Two Enzymatic Phases in Active Sulfate Synthesis. Journal of Biological Chemistry. 1958 Sep;233(3):681–5. doi: 10.1016/s0021-9258(18)64727-1.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Sulfate

Formula: H2SO4 (97.9673812)

CAS ID: 7664-93-9

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.25 adenylyl-sulfate kinase ATP:adenylyl-sulfate 3'-phosphotransferase


Proteins

Protein ID name full name
Q02196 MET14 Adenylyl-sulfate kinase