MAPK family signaling cascades

Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiol Rev. 2012 Apr;92(2):689–737. doi: 10.1152/physrev.00028.2011. PMID: 22535895.; Plotnikov A, Zehorai E, Procaccia S, Seger R. The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2011 Sep;1813(9):1619–33. doi: 10.1016/j.bbamcr.2010.12.012.; Cargnello M, Roux PP. Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev. 2011 Mar;75(1):50–83. PMID: 21372320; PMCID: PMC3063353.; Coulombe P, Meloche S. Atypical mitogen-activated protein kinases: Structure, regulation and functions. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2007 Aug;1773(8):1376–87. doi: 10.1016/j.bbamcr.2006.11.001.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

Palmostatin B

Formula: C23H36O4 (376.2613456)

CAS ID:



Enzyme

EC Number name full name note
3.1.2.-
2.5.1.58 protein farnesyltransferase farnesyl-diphosphate:protein-cysteine farnesyltransferase
2.5.1.59 protein geranylgeranyltransferase type I geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.1.2.22 palmitoyl[protein] hydrolase palmitoyl[protein] hydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name
P19073 CDC42 Cell division control protein 42
P22007 RAM1 Protein farnesyltransferase subunit beta
P29703 RAM2 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Q00684 CDC14 Tyrosine-protein phosphatase CDC14
Q03497 STE20 Serine/threonine-protein kinase STE20
Q12354 APTH1_YEAST Acyl-protein thioesterase 1