TNFR2 non-canonical NF-kB pathway

Gardam S, Brink R. Non-Canonical NF-?B Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures. Front Immunol. 2014 Jan 06;4():509. PMID: 24432023; PMCID: PMC3880999.; Hostager BS, Bishop GA. CD40-Mediated Activation of the NF-?B2 Pathway. Front Immunol. 2013 Nov 15;4():376. PMID: 24298274; PMCID: PMC3828524.; Razani B, Reichardt AD, Cheng G. Non-canonical NF-?B signaling activation and regulation: principles and perspectives. Immunol Rev. 2011 Nov;244(1):44–54. doi: 10.1111/j.1600-065x.2011.01059.x. PMID: 22017430.; Naudé PJW, den Boer JA, Luiten PGM, Eisel ULM. Tumor necrosis factor receptor cross-talk. The FEBS Journal. 2011 Feb 08;278(6):888–98. doi: 10.1111/j.1742-4658.2011.08017.x.; Sun SC. Non-canonical NF-?B signaling pathway. Cell Res. 2011 Jan;21(1):71–85. PMID: 21173796; PMCID: PMC3193406.; Faustman D, Davis M. TNF receptor 2 pathway: drug target for autoimmune diseases. Nat Rev Drug Discov. 2010 Jun;9(6):482–93. doi: 10.1038/nrd3030. PMID: 20489699.; Silke J, Brink R. Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs. Cell Death Differ. 2010 Jan;17(1):35–45. doi: 10.1038/cdd.2009.114. PMID: 19680262.; Häcker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006 Oct 17;2006(357):re13. doi: 10.1126/stke.3572006re13. PMID: 17047224.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)


Proteins

Protein ID name full name
Q01389 BCK1 Serine/threonine-protein kinase BCK1/SLK1/SSP31