CLEC7A (Dectin-1) signaling

Plato A, Willment JA, Brown GD. C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways. International Reviews of Immunology. 2013 Apr 09;32(2):134–56. doi: 10.3109/08830185.2013.777065.; Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011 Apr 28;472(7344):471–5. PMID: 21525931; PMCID: PMC3084546.; Reid DM, Gow NA, Brown GD. Pattern recognition: recent insights from Dectin-1. Current Opinion in Immunology. 2009 Feb;21(1):30–7. doi: 10.1016/j.coi.2009.01.003.; Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol. 2009 Feb;10(2):203–13. doi: 10.1038/ni.1692. PMID: 19122653.; Underhill DM, Rossnagle E, Lowell CA, Simmons RM. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood. 2005 Oct 01;106(7):2543–50. PMID: 15956283; PMCID: PMC1895265.; Herre J, Gordon S, Brown GD. Dectin-1 and its role in the recognition of beta-glucans by macrophages. Mol Immunol. 2004 Feb;40(12):869–76. doi: 10.1016/j.molimm.2003.10.007. PMID: 14698225.; Brown GD, Herre J, Williams DL, Willment JA, Marshall AS, Gordon S. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med. 2003 May 05;197(9):1119–24. PMID: 12719478; PMCID: PMC2193964.; Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med. 2003 May 05;197(9):1107–17. PMID: 12719479; PMCID: PMC2193968.

Metabolites

beta-D-Glucose

Formula: C6H12O6 (180.0633852)

CAS ID: 492-61-5

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
3.4.22.61 caspase-8
6.2.1.64 E1 NEDD8-activating enzyme [NEDD8 protein]:[E1 NEDD8-activating enzyme] ligase (AMP-forming)


Proteins

Protein ID name full name