FCERI mediated Ca+2 mobilization

Siraganian RP, de Castro RO, Barbu EA, Zhang J. Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants. FEBS Letters. 2010 Aug 07;584(24):4933–40. doi: 10.1016/j.febslet.2010.08.006.; Kambayashi T, Koretzky GA. Proximal signaling events in Fc epsilon RI-mediated mast cell activation. J Allergy Clin Immunol. 2007 Mar;119(3):544–52; quiz 553. doi: 10.1016/j.jaci.2007.01.017. PMID: 17336609.; Ebinu JO, Stang SL, Teixeira C, Bottorff DA, Hooton J, Blumberg PM, Barry M, Bleakley RC, Ostergaard HL, Stone JC. RasGRP links T-cell receptor signaling to Ras. 2000 May 15;95(10):3199–203. doi: 10.1182/blood.v95.10.3199.010k37_3199_3203.; Hoth M, Penner R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature. 1992 Jan 23;355(6358):353–6. doi: 10.1038/355353a0. PMID: 1309940.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)


Proteins

Protein ID name full name