Dual incision in TC-NER

Epshtein V, Kamarthapu V, McGary K, Svetlov V, Ueberheide B, Proshkin S, Mironov A, Nudler E. UvrD facilitates DNA repair by pulling RNA polymerase backwards. Nature. 2014 Jan 16;505(7483):372–7. PMID: 24402227; PMCID: PMC4471481.; Vermeulen W, Fousteri M. Mammalian Transcription-Coupled Excision Repair. Cold Spring Harbor Perspectives in Biology. 2013 Aug 01;5(8):a012625. doi: 10.1101/cshperspect.a012625.; Staresincic L, Fagbemi AF, Enzlin JH, Gourdin AM, Wijgers N, Dunand-Sauthier I, Giglia-Mari G, Clarkson SG, Vermeulen W, Schärer OD. Coordination of dual incision and repair synthesis in human nucleotide excision repair. EMBO J. 2009 Apr 22;28(8):1111–20. PMID: 19279666; PMCID: PMC2683701.; Hanawalt PC, Spivak G. Transcription-coupled DNA repair: two decades of progress and surprises. Nature Reviews Molecular Cell Biology. 2008 Dec;9(12):958–70. doi: 10.1038/nrm2549.; Sarker AH, Tsutakawa SE, Kostek S, Ng C, Shin DS, Peris M, Campeau E, Tainer JA, Nogales E, Cooper PK. Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome. Mol Cell. 2005 Oct 28;20(2):187–98. doi: 10.1016/j.molcel.2005.09.022. PMID: 16246722.; Lee K, Wang D, Lippard SJ, Sharp PA. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proc. Natl. Acad. Sci. U.S.A. 2002 Mar 19;99(7):4239–44. doi: 10.1073/pnas.072068399.; Donahue BA, Yin S, Taylor JS, Reines D, Hanawalt PC. Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template. Proc. Natl. Acad. Sci. U.S.A. 1994 Aug 30;91(18):8502–6. doi: 10.1073/pnas.91.18.8502.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
3.4.19.12 ubiquitinyl hydrolase 1
5.6.2.4 DNA 3'-5' helicase DNA 3'-5' helicase (ATP-hydrolysing)


Proteins

Protein ID name full name