DNA Double-Strand Break Repair

Ciccia A, Elledge SJ. The DNA Damage Response: Making It Safe to Play with Knives. Molecular Cell. 2010 Oct;40(2):179–204. doi: 10.1016/j.molcel.2010.09.019.; Rothkamm K, Krüger I, Thompson LH, Lübrich M. Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle. Molecular and Cellular Biology. 2003 Aug 01;23(16):5706–15. doi: 10.1128/mcb.23.16.5706-5715.2003.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

2''-O-acetyl-ADP-D-ribose(2-)

Formula: C17H23N5O15P2 (599.0665868000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.4.19.12 ubiquitinyl hydrolase 1
3.6.4.12 DNA helicase


Proteins

Protein ID name full name