Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Yang W. An overview of Y-Family DNA polymerases and a case study of human DNA polymerase ?. Biochemistry. 2014 May 06;53(17):2793–803. PMID: 24716551; PMCID: PMC4018060.; Masutani C, Kusumoto R, Iwai S, Hanaoka F. Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J. 2000 Jun 15;19(12):3100–9. PMID: 10856253; PMCID: PMC203367.; Lindahl T, Wood RD. Quality control by DNA repair. Science. 1999 Dec 03;286(5446):1897–905. doi: 10.1126/science.286.5446.1897. PMID: 10583946.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.11.-
2.3.2.23 E2 ubiquitin-conjugating enzyme S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
2.7.7.7 DNA-directed DNA polymerase deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
3.4.19.12 ubiquitinyl hydrolase 1
3.6.4.6 vesicle-fusing ATPase ATP phosphohydrolase (vesicle-fusing)


Proteins

Protein ID name full name